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Fifty years ago, Eugene Garfield published the Science Citation Index (SCI), the first systematic effort to track citations in the scientific literature. Nature’s news team wondered which were the most highly-cited papers of all time, so asked Thomson Reuters and Google for their top 100. They are not what you might think. Watson and Crick on DNA structure misses out, along with many other historic discoveries. Instead, methods and software papers dominate the lists.

Find out more at nature.com/top100



The discovery of high-temperature superconductors, the determination of DNA’s double-helix structure, the first observations that the expansion of the Universe is accelerating — all of these breakthroughs won Nobel prizes and international acclaim. Yet none of the papers that announced them comes anywhere close to ranking among the 100 most highly cited papers of all time.

It takes a staggering 12,119 citations to rank in the top 100 — and that many of the world’s most famous papers do not make the cut.

The most cited work in history, for example, is a 1951 paper describing an assay to determine the amount of protein in a solution. It has now gathered more than 305,000 citations — a recognition that always puzzled its lead author...

Would mathematics exist if people didn't? Did we create mathematical concepts to help us understand the world around us, or is math the native language of the universe itself? Jeff Dekofsky traces some famous arguments in this ancient and hotly debated question.

Multi-dose flu shot has only 25 mcg of mercury - most commercial fish contain 23 mcg of mercury per 8 ounces of fish http://buff.ly/11CTRPw

Are multi-dose vials less expensive?

Economics are a bit complicated due to wastage with multiple vials:

Single versus multi-dose vaccine vials: an economic computational model
http://www.ncbi.nlm.nih.gov/pubmed/20566395

Most of the Western world, apart from the US, has moved on to single vials:
http://www.medscape.com/viewarticle/733986

Whenever possible, CDC recommends that single-use vials be used and that multi-dose vials of medication be assigned to a single patient to reduce the risk of disease transmission (http://www.cdc.gov/injectionsafety/patients/syringeReuse_faqs.html).

Where to get a thimerosal/mercury-free flu shot?

Many local Costco stores carry only single vials and the cost is $14.99 if no insurance is used. The availability of additional options may improve immunization rates.

Search for a Costco pharmacy near you here, and call them to verify availability: Warehouse Locations - Costco: www.costco.com/warehouse/locator.aspx

Personal Flu Stories - CDC:



Each year in the US, nearly 20,000 children under age 5 are hospitalized due to flu-related complications. CDC recommends that children aged six months through 18 years old get a flu vaccination. Moving personal stories help parents and caregivers learn about the dangers of influenza to children and the benefits of vaccination.

Image source: Influenza virus, Wikipedia, public domain.

Given the importance of a good night's sleep, how do you pick the best possible bedtime? WSJ's Heidi Mitchell and Stanford University's Dr. Rafael Pelayo discuss with Tanya Rivero.



Related:

What Makes A Great Bedtime? | Craig Canapari, MD http://bit.ly/1vstZzJ
Shift workers and people who get jet lag may gain weight because they dusturb their "inside garden" (gut microbes) buff.ly/1vzaXci

A 65-yo female patient received a standard-dose flu shot already this season. Should he get the high-dose shot too? Or try to get a second regular flu shot?

The simple answer is no. The patients should consider herself immunized. Studies show that getting a delayed second dose doesn't necessarily increase antibody response, and there's some concern that it might actually have a negative effect on the immunity. If you've already had the regular seasonal dose, wait until next year for another dose.


Image of the H1N1 Influenza Virus, CDC.

From CDC's Immunize.org website:

Sometimes patients age 65 years and older who have received the standard-dose influenza vaccine hear about the high-dose product (Fluzone High-Dose, sanofi) and want to receive that, too. Is this okay to administer?

No. ACIP does not recommend that anyone receive more than one dose of influenza vaccine in a season except for certain children age 6 months through 8 years for whom two doses are recommended.

Would giving an older patient 2 doses of standard-dose influenza vaccine be the same as administering the high-dose product?

No, and this is not recommended.

References:

New High-Dose Flu Shot for Older Americans: Answers to Flu Season Questions - AARP http://buff.ly/1ttjluQ

Ask the Experts about Influenza Vaccines - CDC experts answer Q&As; http://buff.ly/1ttjn6e

In this video, the BMJ's research team discuss what they look for in a paper submitted for publication.

They discuss some of the pitfalls authors fall into when writing up their research, and how to present some of the information that all journals will require.



More BMJ-specific info here: http://www.bmj.com/about-bmj/resources-authors

Here are my suggestions for some of the top articles related to healthcare social media (#HCSM) in the past 2-4 weeks:

15 Lessons from 15 Years of Blogging: Link to everything you create elsewhere on the web. And if possible, save a copy of it on your own blog. Things disappear so quickly, and even important work can slip your mind months or years later when you want to recall it. If it's in one, definitive place, you'll be glad for it.

Always write with the idea that what you're sharing will live for months and years and decades. Having a long-term perspective in mind is an incredibly effective tool for figuring out whether a topic is meaningful or not, and for encouraging a kinder, more thoughtful perspective.

Your blog can change your life in a month. If you want to understand an idea, or become a meaningful voice on a topic, or change your own thinking about a concept, write a little bit about it every day for a month.

http://buff.ly/1pwjuWg

Too many crying babies: a systematic review of pain management practices during immunizations on YouTube http://buff.ly/1j4PHaz

Unprofessional behavior is prevalent among surgical residents who use Facebook (study) http://buff.ly/1j4POCV

Support network: People discussing their weight loss are happier with Twitter (more support, less negativity) than Facebook and in-person relationships http://buff.ly/1j4PUKK

A Facebook teaching forum was set up in a London Hospital for undergraduate medical students: 92% approved http://buff.ly/1j4QacM

Why Wikipedia matters for healthcare: it dominates search results for medical information - BMJ http://buff.ly/1vOMP1Y

YouTube as a source of patient information for lumbar discectomy. http://buff.ly/1qLVd4m

The Anatomy of a Scientific Rumor http://buff.ly/TP1v4K

Email Alerts Services You Should Use http://buff.ly/TP2yBC

Are You Tweeting Your Marriage Away? Time spent on social media can create friction in relationships (study) http://buff.ly/1ooRKmc

Twitter: an opportunity for public health campaigns : The Lancet http://buff.ly/U7drPJ

Do you "like" my photo? Facebook use may increase eating disorder risk http://buff.ly/WqD284

Cleveland Clinic has a blog for patients - Health Hub http://buff.ly/1yHsRtt and a blog for physicians - Consult QD http://buff.ly/1yHsr6g

The articles were selected from Twitter @DrVes and RSS subscriptions. Please feel free to send suggestions for articles to clinicalcases at gmail.com and you will receive an acknowledgement in the next edition of this publication.